ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts

HLA-C arose during evolution of pregnancy in the great apes 10 to 15 million years ago. It has a dual function on placental extravillous trophoblasts (EVTs) as it contributes to both tolerance and immunity at the maternal–fetal interface. The mode of its regulation is of considerable interest in con...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Li, Qin, Meissner, Torsten B., Wang, Fang, Du, Ziming, Ma, Sai, Kshirsagar, Sarika, Tilburgs, Tamara, Buenrostro, Jason D., Uesugi, Motonari, Strominger, Jack L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936349/
https://ncbi.nlm.nih.gov/pubmed/33622787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025512118
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