ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts

HLA-C arose during evolution of pregnancy in the great apes 10 to 15 million years ago. It has a dual function on placental extravillous trophoblasts (EVTs) as it contributes to both tolerance and immunity at the maternal–fetal interface. The mode of its regulation is of considerable interest in con...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Li, Qin, Meissner, Torsten B., Wang, Fang, Du, Ziming, Ma, Sai, Kshirsagar, Sarika, Tilburgs, Tamara, Buenrostro, Jason D., Uesugi, Motonari, Strominger, Jack L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936349/
https://ncbi.nlm.nih.gov/pubmed/33622787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025512118
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge