ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts

HLA-C arose during evolution of pregnancy in the great apes 10 to 15 million years ago. It has a dual function on placental extravillous trophoblasts (EVTs) as it contributes to both tolerance and immunity at the maternal–fetal interface. The mode of its regulation is of considerable interest in con...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Qin, Meissner, Torsten B., Wang, Fang, Du, Ziming, Ma, Sai, Kshirsagar, Sarika, Tilburgs, Tamara, Buenrostro, Jason D., Uesugi, Motonari, Strominger, Jack L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936349/
https://ncbi.nlm.nih.gov/pubmed/33622787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025512118
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker