Linker domain function predicts pathogenic MLH1 missense variants

The pathogenic consequences of 369 unique human HsMLH1 missense variants has been hampered by the lack of a detailed function in mismatch repair (MMR). Here single-molecule images show that HsMSH2-HsMSH6 provides a platform for HsMLH1-HsPMS2 to form a stable sliding clamp on mismatched DNA. The mech...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: London, James, Martín-López, Juana, Yang, Inho, Liu, Jiaquan, Lee, Jong-Bong, Fishel, Richard
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936337/
https://ncbi.nlm.nih.gov/pubmed/33619096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019215118
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