Aerosol delivery of synthetic DNA containing CpG motifs in broiler chicks at hatch under field conditions using a commercial-scale prototype nebulizer provided protection against lethal Escherichia coli septicemia

Synthetic DNA containing CpG motifs (CpG-ODN) are potent innate immune stimulators in neonatal and adult broiler chickens against bacterial septicemia. We have recently demonstrated that intrapulmonary (IPL) delivery of CpG-ODN as microdroplets under laboratory conditions can protect neonatal chicke...

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Pubblicato in:Poult Sci
Autori principali: Goonewardene, K.B., Popowich, S., Gebhardt, S., Gunawardana, T., Gupta, A., Kurukulasuriya, S., Karunarathna, R., Liu, M., Chow-Lockerbie, B., Ayalew, L., Ahmed, K.A., Kamali, Houman, Tikoo, S.K., Foldvari, M., Willson, P., Boire, J., Roberts, K., Ambrose, N., Simonson, C., Gomis, S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
Immunology, Health and Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936187/
https://ncbi.nlm.nih.gov/pubmed/33652543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psj.2020.12.031
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