Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export

T-cell development depends on the thymic microenvironment, in which endothelial cells (ECs) play a vital role. Interestingly, vascular permeability of the thymic cortex is lower than in other organs, suggesting the existence of a blood–thymus barrier (BTB). On the other hand, blood-borne molecules a...

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Publicat a:Int Immunol
Autors principals: Nagatake, Takahiro, Zhao, Yan-Chun, Ito, Takeshi, Itoh, Masahiko, Kometani, Kohei, Furuse, Mikio, Saika, Azusa, Node, Eri, Kunisawa, Jun, Minato, Nagahiro, Hamazaki, Yoko
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936066/
https://ncbi.nlm.nih.gov/pubmed/33038259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxaa069
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