Engineering subtilisin proteases that specifically degrade active RAS

We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by cleaving a conserved sequence in switch 2. RAS is a signaling protein that, when mutated, drives a third of human cancers. To generate high specificity for the RAS tar...

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Veröffentlicht in:Commun Biol
Hauptverfasser: Chen, Yingwei, Toth, Eric A., Ruan, Biao, Choi, Eun Jung, Simmerman, Richard, Chen, Yihong, He, Yanan, Wang, Ruixue, Godoy-Ruiz, Raquel, King, Harlan, Custer, Gregory, Travis Gallagher, D., Rozak, David A., Solomon, Melani, Muro, Silvia, Weber, David J., Orban, John, Fuerst, Thomas R., Bryan, Philip N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935941/
https://ncbi.nlm.nih.gov/pubmed/33674772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01818-7
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