Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown. Bortezomib (BTZ) is the first proteasome inhibitor-based anticancer drug appr...

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Publicado en:Cell Death Dis
Autores principales: Su, Zhipeng, Han, Shengnan, Jin, Qiumei, Zhou, Ningning, Lu, Junwan, Shangguan, Fugen, Yu, Shiyi, Liu, Yongzhang, Wang, Lu, Lu, Jianglong, Li, Qun, Cai, Lin, Wang, Chengde, Tian, Xiaohe, Chen, Lingyan, Zheng, Weiming, Lu, Bin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935936/
https://ncbi.nlm.nih.gov/pubmed/33674562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03535-9
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