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Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas

Atoh7 has been believed to be essential for establishing the retinal ganglion cell (RGC) lineage, and Pou4f2 and Isl1 are known to regulate RGC specification and differentiation. Here we report our further study of the roles of these transcription factors. Using bulk RNA-seq, we identify genes regul...

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Vydáno v:Nat Commun
Hlavní autoři: Wu, Fuguo, Bard, Jonathan E., Kann, Julien, Yergeau, Donald, Sapkota, Darshan, Ge, Yichen, Hu, Zihua, Wang, Jie, Liu, Tao, Mu, Xiuqian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935890/
https://ncbi.nlm.nih.gov/pubmed/33674582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21704-4
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