Patterns of Resistance Differ in Patients with Acute Myeloid Leukemia Treated with Type I versus Type II FLT3 Inhibitors

Despite promising results with FLT3 inhibitors (FLT3i), response durations remain short. We studied pretreatment and relapse bone marrow samples from patients with FLT3-mutated acute myeloid leukemia (AML) treated with FLT3i-based therapies (secondary resistance cohort), and pretreatment bone marrow...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Main Authors: Alotaibi, Ahmad S., Yilmaz, Musa, Kanagal-Shamanna, Rashmi, Loghavi, Sanam, Kadia, Tapan M., DiNardo, Courtney D., Borthakur, Gautam, Konopleva, Marina, Pierce, Sherry A., Wang, Sa A., Tang, Guilin, Guerra, Veronica, Samra, Bachar, Pemmaraju, Naveen, Jabbour, Elias, Short, Nicholas J., Issa, Ghayas C., Ohanian, Maro, Garcia-Manero, Guillermo, Bhalla, Kapil N., Patel, Keyur P., Takahashi, Koichi, Andreeff, Michael, Cortes, Jorge E., Kantarjian, Hagop M., Ravandi, Farhad, Daver, Naval
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2020
Assuntos:
Research Brief
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935111/
https://ncbi.nlm.nih.gov/pubmed/33681815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0143
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