Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease

IL-33 is a key mediator of chronic airway disease driven by type 2 immune pathways, yet the nonclassical secretory mechanism for this cytokine remains undefined. We performed a comprehensive analysis in human airway epithelial cells, which revealed that tonic IL-33 secretion is dependent on the cera...

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Pubblicato in:JCI Insight
Autori principali: Katz-Kiriakos, Ella, Steinberg, Deborah F., Kluender, Colin E., Osorio, Omar A., Newsom-Stewart, Catie, Baronia, Arjun, Byers, Derek E., Holtzman, Michael J., Katafiasz, Dawn, Bailey, Kristina L., Brody, Steven L., Miller, Mark J., Alexander-Brett, Jennifer
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934940/
https://ncbi.nlm.nih.gov/pubmed/33507882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136166
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