Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans

Hepatocellular death contributes to progression of alcohol–associated (ALD-associated) and non–alcohol-associated (NAFL/NASH) liver diseases. However, receptor-interaction protein kinase 3 (RIP3), an intermediate in necroptotic cell death, contributes to injury in murine models of ALD but not NAFL/N...

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Publicado en:JCI Insight
Autores principales: Miyata, Tatsunori, Wu, Xiaoqin, Fan, Xiude, Huang, Emily, Sanz-Garcia, Carlos, Ross, Christina K. Cajigas-Du, Roychowdhury, Sanjoy, Bellar, Annette, McMullen, Megan R., Dasarathy, Jaividhya, Allende, Daniela S., Caballeria, Joan, Sancho-Bru, Pau, McClain, Craig J., Mitchell, Mack, McCullough, Arthur J., Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Dasarathy, Srinivasan, Nagy, Laura E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934930/
https://ncbi.nlm.nih.gov/pubmed/33616081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140180
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