MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

BACKGROUND & AIMS: Autophagy maintains cellular homeostasis and plays a critical role in the development of non-alcoholic fatty liver and steatohepatitis. The pseudokinase mixed lineage kinase domain-like (MLKL) is a key downstream effector of receptor interacting protein kinase 3 (RIP3) in the...

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Udgivet i:J Hepatol
Main Authors: Wu, Xiaoqin, Poulsen, Kyle L., Sanz-Garcia, Carlos, Huang, Emily, McMullen, Megan R., Roychowdhury, Sanjoy, Dasarathy, Srinivasan, Nagy, Laura E.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438259/
https://ncbi.nlm.nih.gov/pubmed/32220583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.03.023
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