Early brainstem ([18F])THK5351 uptake is linked to cortical hyperexcitability in healthy aging

BACKGROUND: Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction. In healthy humans, misfolde...

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Vydáno v:JCI Insight
Hlavní autoři: Van Egroo, Maxime, Chylinski, Daphne, Narbutas, Justinas, Besson, Gabriel, Muto, Vincenzo, Schmidt, Christina, Marzoli, Davide, Cardone, Paolo, Vandeleene, Nora, Grignard, Martin, Luxen, André, Salmon, Eric, Lambert, Christian, Bastin, Christine, Collette, Fabienne, Phillips, Christophe, Maquet, Pierre, Bahri, Mohamed Ali, Balteau, Evelyne, Vandewalle, Gilles
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934880/
https://ncbi.nlm.nih.gov/pubmed/33290274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142514
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