Early brainstem ([18F])THK5351 uptake is linked to cortical hyperexcitability in healthy aging

BACKGROUND: Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction. In healthy humans, misfolde...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Van Egroo, Maxime, Chylinski, Daphne, Narbutas, Justinas, Besson, Gabriel, Muto, Vincenzo, Schmidt, Christina, Marzoli, Davide, Cardone, Paolo, Vandeleene, Nora, Grignard, Martin, Luxen, André, Salmon, Eric, Lambert, Christian, Bastin, Christine, Collette, Fabienne, Phillips, Christophe, Maquet, Pierre, Bahri, Mohamed Ali, Balteau, Evelyne, Vandewalle, Gilles
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Clinical Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934880/
https://ncbi.nlm.nih.gov/pubmed/33290274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142514
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker