Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

CIS43 is a potent neutralizing human mAb that targets a highly conserved “junctional” epitope in the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). Enhancing the durability of CIS43 in vivo will be important for clinical translation. Here, 2 approaches were used to improve the durabili...

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Vydáno v:JCI Insight
Hlavní autoři: Kisalu, Neville K., Pereira, Lais D., Ernste, Keenan, Flores-Garcia, Yevel, Idris, Azza H., Asokan, Mangaiarkarasi, Dillon, Marlon, MacDonald, Scott, Shi, Wei, Chen, Xuejun, Pegu, Amarendra, Schön, Arne, Zavala, Fidel, Balazs, Alejandro B., Francica, Joseph R., Seder, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934869/
https://ncbi.nlm.nih.gov/pubmed/33332286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143958
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