Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

Treatment of HIV infection with either antiretroviral (ARV) therapy or neutralizing monoclonal antibodies (NAbs) leads to a reduction in HIV plasma virus. Both ARVs and NAbs prevent new rounds of viral infection, but NAbs may have the additional capacity to accelerate the loss of virus-infected cell...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Asokan, Mangaiarkarasi, Dias, Joana, Liu, Cuiping, Maximova, Anna, Ernste, Keenan, Pegu, Amarendra, McKee, Krisha, Shi, Wei, Chen, Xuejun, Almasri, Cassandra, Promsote, Wanwisa, Ambrozak, David R., Gama, Lucio, Hu, Jianfei, Douek, Daniel C., Todd, John-Paul, Lifson, Jeffrey D., Fourati, Slim, Sekaly, Rafick P., Crowley, Andrew R., Ackerman, Margaret E., Ko, Sung Hee, Kilam, Divya, Boritz, Eli A., Liao, Laura E., Best, Katharine, Perelson, Alan S., Mascola, John R., Koup, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414046/
https://ncbi.nlm.nih.gov/pubmed/32690707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008236117
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