Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination

Recombinant adeno-associated virus (rAAV) vectors have the unique ability to promote targeted integration of transgenes via homologous recombination at specified genomic sites, reaching frequencies of 0.1%–1%. We studied genomic parameters that influence targeting efficiencies on a large scale. To d...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Spector, Laura P., Tiffany, Matthew, Ferraro, Nicole M., Abell, Nathan S., Montgomery, Stephen B., Kay, Mark A.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934627/
https://ncbi.nlm.nih.gov/pubmed/33248247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.11.025
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