10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties

A novel series of anthracenyl-isoxazole amide (AIM) antitumor agents containing N-heterocycles in the 10 position (N-het) were synthesized using palladium cross-coupling. The unique steric environment of the N-het-AIMs required individual optimization in each case. Lanthanide mediated double activat...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Weaver, Matthew J., Stump, Sascha, Campbell, Michael J., Backos, Donald S., Li, Chun, Reigan, Philip, Adams, Earle, Beall, Howard D., Natale, Nicholas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933047/
https://ncbi.nlm.nih.gov/pubmed/33038788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115781
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