Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis

High-throughput T-cell receptor repertoire sequencing constitutes a powerful tool to study T cell responses at the clonal level. However, it does not give information on the functional phenotype of the responding clones and lacks a statistical framework for quantitative evaluation. To overcome this,...

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Udgivet i:Front Immunol
Main Authors: Pollastro, Sabrina, de Bourayne, Marie, Balzaretti, Giulia, Jongejan, Aldo, van Schaik, Barbera D. C., Niewold, Ilse T. G., van Kampen, Antoine H. C., Maillère, Bernard, de Vries, Niek
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932994/
https://ncbi.nlm.nih.gov/pubmed/33679697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.609624
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