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Zbtb20 restrains CD8 T cell immunometabolism and restricts memory differentiation and anti-tumor immunity
CD8 T cell differentiation is orchestrated by dynamic metabolic changes that direct activation, proliferation, cytotoxic function and epigenetic changes. We report that the BTB-ZF family transcriptional repressor Zbtb20 negatively regulates CD8 T cell metabolism and memory differentiation in mice. E...
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| Опубликовано в: : | J Immunol |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7931848/ https://ncbi.nlm.nih.gov/pubmed/32998985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000459 |
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