Trastuzumab Blocks the Receiver Function of HER2 Leading to the Population Shifts of HER2-Containing Homodimers and Heterodimers

HER2, a member of the Erythroblastosis Protein B/Human Epidermal Growth Factor Receptor (ErbB/HER) family of receptor tyrosine kinase, is overexpressed in 20~30% of human breast cancers. Trastuzumab, a HER2-targeted therapeutic monoclonal antibody, was developed to interfere with the homodimerizatio...

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Vydáno v:Antibodies (Basel)
Hlavní autoři: Zhao, Jun, Mohan, Nishant, Nussinov, Ruth, Ma, Buyong, Wu, Wen Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931022/
https://ncbi.nlm.nih.gov/pubmed/33557368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib10010007
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