Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies

Granulomatosis with polyangiitis (GPA) is a rare but serious necrotizing auto-immune vasculitis. GPA is mostly associated with the presence of Anti-Neutrophil Cytoplasmic Antibody (ANCA) targeting proteinase 3 (PR3-ANCA), a serine protease contained in neutrophil granules but also exposed at the mem...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Granel, Jérôme, Korkmaz, Brice, Nouar, Dalila, Weiss, Stefanie A. I., Jenne, Dieter E., Lemoine, Roxane, Hoarau, Cyrille
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930335/
https://ncbi.nlm.nih.gov/pubmed/33679731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.571933
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