4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase. PR3-ANCA binding to membrane-bound PR3 on neutrophils induce their auto-immune...

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Udgivet i:Front Immunol
Main Authors: Granel, Jérôme, Lemoine, Roxane, Morello, Eric, Gallais, Yann, Mariot, Julie, Drapeau, Marion, Musnier, Astrid, Poupon, Anne, Pugnière, Martine, Seren, Seda, Nouar, Dalila, Gouilleux-Gruart, Valérie, Watier, Hervé, Korkmaz, Brice, Hoarau, Cyrille
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546423/
https://ncbi.nlm.nih.gov/pubmed/33101296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.573040
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