Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However, the extent of inter- and intra-tumor heterogeneity is not established. Here we use digital spatial profiling (DSP) technology to quantitate transcript and protein abundance in spatially-distinct regions of mPCs. By...

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Vydáno v:Nat Commun
Hlavní autoři: Brady, Lauren, Kriner, Michelle, Coleman, Ilsa, Morrissey, Colm, Roudier, Martine, True, Lawrence D., Gulati, Roman, Plymate, Stephen R., Zhou, Zoey, Birditt, Brian, Meredith, Rhonda, Geiss, Gary, Hoang, Margaret, Beechem, Joseph, Nelson, Peter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930198/
https://ncbi.nlm.nih.gov/pubmed/33658518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21615-4
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