Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a distinct airway immunometabolic response dominated by the release of the electrophilic metabolite, itaconate. The itaconate...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Tomlinson, Kira L., Lung, Tania Wong Fok, Dach, Felix, Annavajhala, Medini K., Gabryszewski, Stanislaw J., Groves, Ryan A., Drikic, Marija, Francoeur, Nancy J., Sridhar, Shwetha H., Smith, Melissa L., Khanal, Sara, Britto, Clemente J., Sebra, Robert, Lewis, Ian, Uhlemann, Anne-Catrin, Kahl, Barbara C., Prince, Alice S., Riquelme, Sebastián A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930111/
https://ncbi.nlm.nih.gov/pubmed/33658521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21718-y
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