Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

Sarcopenia is a degenerative condition that consists in age-induced atrophy and functional decline of skeletal muscle cells (myofibers). A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been extensively tested. Here,...

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Publicado no:Nat Commun
Main Authors: Hunt, Liam C., Schadeberg, Bronwen, Stover, Jared, Haugen, Benard, Pagala, Vishwajeeth, Wang, Yong-Dong, Puglise, Jason, Barton, Elisabeth R., Peng, Junmin, Demontis, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930053/
https://ncbi.nlm.nih.gov/pubmed/33658508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21738-8
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