Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Trans-acyltransferase polyketide synthases (trans-AT PKSs) are bacterial multimodular enzymes that biosynthesize diverse pharmaceutically and ecologically important polyketides. A notable feature of this natural product class is the existence of chemical hybrids that combine core moieties from diffe...

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Udgivet i:Nat Commun
Main Authors: Helfrich, Eric J. N., Ueoka, Reiko, Chevrette, Marc G., Hemmerling, Franziska, Lu, Xiaowen, Leopold-Messer, Stefan, Minas, Hannah A., Burch, Adrien Y., Lindow, Steven E., Piel, Jörn, Medema, Marnix H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930024/
https://ncbi.nlm.nih.gov/pubmed/33658492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21163-x
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