Genome Mining of Oxidation Modules in trans‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

Bacterial trans‐acyltransferase polyketide synthases (trans‐AT PKSs) are multimodular megaenzymes that biosynthesize many bioactive natural products. They contain a remarkable range of domains and module types that introduce different substituents into growing polyketide chains. As one such modifica...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Ueoka, Reiko, Meoded, Roy A., Gran‐Scheuch, Alejandro, Bhushan, Agneya, Fraaije, Marco W., Piel, Jörn
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586987/
https://ncbi.nlm.nih.gov/pubmed/32040255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201916005
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