Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport

Human excitatory amino acid transporter 3 (hEAAT3) mediates glutamate uptake in neurons, intestine, and kidney. Here, we report cryo-EM structures of hEAAT3 in several functional states where the transporter is empty, bound to coupled sodium ions only, or fully loaded with three sodium ions, a proto...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Qiu, Biao, Matthies, Doreen, Fortea, Eva, Yu, Zhiheng, Boudker, Olga
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7929514/
https://ncbi.nlm.nih.gov/pubmed/33658209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf5814
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