Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow

[Image: see text] The scale-up of a chiral bicyclic homopiperazine of pharmaceutical interest was investigated. The outcome and safety profile of a key batch ring-expansion step via Schmidt rearrangement was improved using continuous-flow chemistry. The selectivity of nitrogen insertion for the ring...

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Detalhes bibliográficos
Publicado no:Org Process Res Dev
Main Authors: Brown, Michael, Aljarah, Mohammed, Asiki, Hannah, Leung, Leo M. H., Smithen, Deborah A., Miller, Natalie, Nemeth, Gabor, Davies, Lawrence, Niculescu-Duvaz, Dan, Zambon, Alfonso, Springer, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928940/
https://ncbi.nlm.nih.gov/pubmed/33679122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.oprd.0c00361
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