Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus

BACKGROUND: REGN3048 and REGN3051 are human monoclonal antibodies (mAb) targeting the spike glycoprotein on the Middle East respiratory syndrome coronavirus (MERS-CoV), which binds to the receptor dipeptidyl peptidase-4 (DPP4) and is necessary for infection of susceptible cells. METHODS: Preclinical...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Sivapalasingam, Sumathi, Saviolakis, George A, Kulcsar, Kirsten, Nakamura, Aya, Conrad, Thomas, Hassanein, Mohamed, Sumner, Giane, Elango, Chinnasamy, Kamal, Mohamed A, Eng, Simon, Kyratsous, Christos A, Musser, Bret J, Frieman, Matthew, Kantrowitz, Joel, Weinreich, David M, Yancopoulos, George, Stahl, Neil, Lipsich, Leah
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928873/
https://ncbi.nlm.nih.gov/pubmed/33507266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiab036
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