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Efficient and flexible Integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation
Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare variants in coding or regulatory regions with complex...
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| 出版年: | PLoS Comput Biol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7928502/ https://ncbi.nlm.nih.gov/pubmed/33606672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007784 |
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