Efficient and flexible Integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation

Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare variants in coding or regulatory regions with complex...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Susak, Hana, Serra-Saurina, Laura, Demidov, German, Rabionet, Raquel, Domènech, Laura, Bosio, Mattia, Muyas, Francesc, Estivill, Xavier, Escaramís, Geòrgia, Ossowski, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928502/
https://ncbi.nlm.nih.gov/pubmed/33606672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007784
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