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Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase

Nucleotide analogs targeting viral RNA polymerase have been proved to be an effective strategy for antiviral treatment and are promising antiviral drugs to combat the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In this study, we developed a robust in vitro nonradio...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Lu, Gaofei, Zhang, Xi, Zheng, Weinan, Sun, Jialei, Hua, Lan, Xu, Lan, Chu, Xin-jie, Ding, Sheng, Xiong, Wen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927875/
https://ncbi.nlm.nih.gov/pubmed/33122171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01508-20
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