Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Sathkumara, Harindra D., Hansen, Karyna, Miranda-Hernandez, Socorro, Govan, Brenda, Rush, Catherine M., Henning, Lars, Ketheesan, Natkunam, Kupz, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927854/
https://ncbi.nlm.nih.gov/pubmed/33046495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01422-20
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