Regioisomerization of Antimalarial Drug WR99210 Explains the Inactivity of a Commercial Stock

WR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite’s dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fused with TS. Accordingly, WR99210 and plasmids e...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Remcho, T. Parks, Guggilapu, Sravanthi D., Cruz, Phillip, Nardone, Glenn A., Heffernan, Gavin, O’Connor, Robert D., Bewley, Carole A., Wellems, Thomas E., Lane, Kristin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927815/
https://ncbi.nlm.nih.gov/pubmed/33077647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01385-20
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