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YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity

The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted high-throughput screening assays on 42,498 compounds to identify NleB/SseK inhibitors. Such small molecules may be useful as mechanistic probe...

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Detalhes bibliográficos
Publicado no:Pathogens
Main Authors: Zhu, Congrui, El Qaidi, Samir, McDonald, Peter, Roy, Anuradha, Hardwidge, Philip R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7926936/
https://ncbi.nlm.nih.gov/pubmed/33672424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens10020253
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