Quantification and Metabolite Identification of Sulfasalazine in Mouse Brain and Plasma Using Quadrupole-Time-of-Flight Mass Spectrometry

Sulfasalazine (SAS), an anti-inflammatory drug with potent cysteine/glutamate antiporter system xc-(SXC) inhibition has recently shown beneficial effects in brain-related diseases. Despite many reports related to central nervous system (CNS) effect of SAS, pharmacokinetics (PK) and metabolite identi...

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Bibliographic Details
Published in:Molecules
Main Authors: Choi, Jangmi, Park, Min-Ho, Shin, Seok-Ho, Byeon, Jin-Ju, Lee, Byeong ill, Park, Yuri, Shin, Young G.
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7926890/
https://ncbi.nlm.nih.gov/pubmed/33671835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26041179
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