Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling

Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied for the determination of carisbamate in rat plasma to sup...

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Bibliografiska uppgifter
I publikationen:Transl Clin Pharmacol
Huvudupphovsmän: Lee, Byeong ill, Lim, Jeong-hyeon, Park, Min-Ho, Shin, Seok-Ho, Byeon, Jin-Ju, Choi, Jang-mi, Park, Seo-jin, Park, Min-jae, Park, Yuri, Shin, Young G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Korean Society for Clinical Pharmacology and Therapeutics 2020
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533164/
https://ncbi.nlm.nih.gov/pubmed/33062628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2020.28.e15
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