Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling

Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied for the determination of carisbamate in rat plasma to sup...

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Detalhes bibliográficos
Publicado no:Transl Clin Pharmacol
Main Authors: Lee, Byeong ill, Lim, Jeong-hyeon, Park, Min-Ho, Shin, Seok-Ho, Byeon, Jin-Ju, Choi, Jang-mi, Park, Seo-jin, Park, Min-jae, Park, Yuri, Shin, Young G.
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Clinical Pharmacology and Therapeutics 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533164/
https://ncbi.nlm.nih.gov/pubmed/33062628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2020.28.e15
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