Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial

IMPORTANCE: Blinatumomab is a CD3/CD19-directed bispecific T-cell engager molecule with efficacy in children with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). OBJECTIVE: To evaluate event-free survival in children with high-risk first-relapse B-ALL after a third consolidation...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Locatelli, Franco, Zugmaier, Gerhard, Rizzari, Carmelo, Morris, Joan D., Gruhn, Bernd, Klingebiel, Thomas, Parasole, Rosanna, Linderkamp, Christin, Flotho, Christian, Petit, Arnaud, Micalizzi, Concetta, Mergen, Noemi, Mohammad, Abeera, Kormany, William N., Eckert, Cornelia, Möricke, Anja, Sartor, Mary, Hrusak, Ondrej, Peters, Christina, Saha, Vaskar, Vinti, Luciana, von Stackelberg, Arend
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2021
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7926287/
https://ncbi.nlm.nih.gov/pubmed/33651091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2021.0987
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