A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

Cancer immunotherapy using T cells redirected with chimeric antigen receptor (CAR) has shown a lot of promise. We have established a single-chain antibody (scFv) generation system in which scFv library-expressing CAR-T cells can be screened appropriately based on their antitumor functions. A variabl...

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Pubblicato in:Commun Biol
Autori principali: Ochi, Toshiki, Maruta, Masaki, Tanimoto, Kazushi, Kondo, Fumitake, Yamamoto, Toshihiro, Kurata, Mie, Fujiwara, Hiroshi, Masumoto, Junya, Takenaka, Katsuto, Yasukawa, Masaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925539/
https://ncbi.nlm.nih.gov/pubmed/33654176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01791-1
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