AXL inhibition induces DNA damage and replication stress in non-small cell lung cancer cells and promotes sensitivity to ATR inhibitors

AXL, a TAM family receptor tyrosine kinase, is increasingly being recognized as a key determinant of resistance to targeted therapies as well as chemotherapy and radiation in non-small cell lung cancer (NSCLC) and other cancers. We further show here that high levels of AXL and EMT were frequently ex...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Ramkumar, Kavya, Stewart, C. Allison, Cargill, Kasey R., Corte, Carminia M. Della, Wang, Qi, Shen, Li, Diao, Lixia, Cardnell, Robert J., Peng, David H., Rodriguez, B. Leticia, Fan, You-Hong, Heymach, John V., Wang, Jing, Gay, Carl M., Gibbons, Don L., Byers, Lauren A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925356/
https://ncbi.nlm.nih.gov/pubmed/33172976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0414
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