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Novel Monoclonal Antibodies Targeting the RRM2 domain of Human TDP-43 Protein

Transactive response DNA-binding protein of 43 kilodaltons (TDP-43) is a 414 amino acid peptide that under physiologic conditions localizes to the nucleus and participates in the regulation of RNA metabolism through two RNA recognition motifs (RRM1 and RRM2). In neurodegenerative diseases, TDP-43 ma...

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Bibliographische Detailangaben
Veröffentlicht in:Neurosci Lett
Hauptverfasser: Trejo-Lopez, Jorge A., Sorrentino, Zachary A., Riffe, Cara J., Lloyd, Grace M., Labuzan, Sydney A., Dickson, Dennis W., Yachnis, Anthony T., Prokop, Stefan, Giasson, Benoit I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924408/
https://ncbi.nlm.nih.gov/pubmed/32905837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.135353
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