Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause life-threatening disorders. Here we explore the use of nuclear genome transfer between unfertilized oocytes of two donors to prevent the transmission of mitochondrial mutations. Nuclear genome transfer did not...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Paull, Daniel, Emmanuele, Valentina, Weiss, Keren A., Treff, Nathan, Stewart, Latoya, Hua, Haiqing, Zimmer, Matthew, Kahler, David J., Goland, Robin S., Noggle, Scott A., Prosser, Robert, Hirano, Michio, Sauer, Mark V., Egli, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924261/
https://ncbi.nlm.nih.gov/pubmed/23254936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11800
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