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Accurate SNV detection in single cells by transposon-based whole-genome amplification of complementary strands

Single-nucleotide variants (SNVs), pertinent to aging and disease, occur sporadically in the human genome, hence necessitating single-cell measurements. However, detection of single-cell SNVs suffers from false positives (FPs) due to intracellular single-stranded DNA damage and the process of whole-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xing, Dong, Tan, Longzhi, Chang, Chi-Han, Li, Heng, Xie, X. Sunney
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923680/
https://ncbi.nlm.nih.gov/pubmed/33593904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013106118
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