Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity

The maintenance of sufficient but nontoxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well established role for iron homeostasis; however, no copper-binding analogs have been found in fungi. Here we demonstrate that, in Aspergil...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Raffa, Nicholas, Won, Tae Hyung, Sukowaty, Andrew, Candor, Kathleen, Cui, Chengsen, Halder, Saayak, Dai, Mingji, Landero-Figueroa, Julio A., Schroeder, Frank C., Keller, Nancy P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2021
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923669/
https://ncbi.nlm.nih.gov/pubmed/33593906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015224118
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