Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity

The maintenance of sufficient but nontoxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well established role for iron homeostasis; however, no copper-binding analogs have been found in fungi. Here we demonstrate that, in Aspergil...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Raffa, Nicholas, Won, Tae Hyung, Sukowaty, Andrew, Candor, Kathleen, Cui, Chengsen, Halder, Saayak, Dai, Mingji, Landero-Figueroa, Julio A., Schroeder, Frank C., Keller, Nancy P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923669/
https://ncbi.nlm.nih.gov/pubmed/33593906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015224118
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