New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain

P2X7 receptors (P2X7Rs) belong to a family of ATP-gated non-selective cation channels. Microglia represent a major cell type expressing P2X7Rs. The activation of microglial P2X7Rs causes the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β). This response has been implicated in ne...

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Vydáno v:Cells
Hlavní autoři: Yamashita, Tomohiro, Kamikaseda, Sawako, Tanaka, Aya, Tozaki-Saitoh, Hidetoshi, Caaveiro, Jose M. M., Inoue, Kazuhide, Tsuda, Makoto
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922706/
https://ncbi.nlm.nih.gov/pubmed/33670748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10020434
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