Limited Sampling Strategy for Determination of Ibrutinib Plasma Exposure: Joint Analyses with Metabolite Data

Therapeutic drug monitoring of ibrutinib is based on the area under the curve of concentration vs. time (AUC(IBRU)) instead of trough concentration (C(min,ss)) because of a limited accumulation in plasma. Our objective was to identify a limited sampling strategy (LSS) to estimate AUC(IBRU) associate...

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Bibliografiske detaljer
Udgivet i:Pharmaceuticals (Basel)
Main Authors: Le Louedec, Félicien, Gallais, Fanny, Thomas, Fabienne, White-Koning, Mélanie, Allal, Ben, Protin, Caroline, Ysebaert, Loïc, Chatelut, Étienne, Puisset, Florent
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922501/
https://ncbi.nlm.nih.gov/pubmed/33670575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14020162
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