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Limited Sampling Strategy for Determination of Ibrutinib Plasma Exposure: Joint Analyses with Metabolite Data
Therapeutic drug monitoring of ibrutinib is based on the area under the curve of concentration vs. time (AUC(IBRU)) instead of trough concentration (C(min,ss)) because of a limited accumulation in plasma. Our objective was to identify a limited sampling strategy (LSS) to estimate AUC(IBRU) associate...
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| Publicado no: | Pharmaceuticals (Basel) |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7922501/ https://ncbi.nlm.nih.gov/pubmed/33670575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14020162 |
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