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Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes. The metabolic consequences of itaconate in cells are diverse and contribute to its regulatory function. Here, we have applied...

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Bibliographische Detailangaben
Veröffentlicht in:Metabolites
Hauptverfasser: Cordes, Thekla, Metallo, Christian M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922098/
https://ncbi.nlm.nih.gov/pubmed/33670656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11020117
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